A Hybrid Computational Method for the Identification of Cell Cycle-regulated Genes

Document type: Conference Papers
Peer reviewed: Yes
Full text:
Author(s): Veselka Boeva, Petia Ivanova, Niklas Lavesson
Title: A Hybrid Computational Method for the Identification of Cell Cycle-regulated Genes
Conference name: IEEE Intelligent Systems
Year: 2010
Pagination: 390-395
ISBN: 978-1-4244-5164-7
Publisher: IEEE press
City: London
Organization: Blekinge Institute of Technology
Department: School of Computing (Sektionen för datavetenskap och kommunikation)
School of Computing S-371 79 Karlskrona
+46 455 38 50 00
http://www.bth.se/com
Authors e-mail: vboeva@tu-plovdiv.bg, petini84@yahoo.com, niklas.lavesson@bth.se
Language: English
Abstract: Gene expression microarrays are the most commonly available source of high-throughput biological data. They have been widely employed in recent years for the definition of cell cycle regulated (or periodically expressed) subsets of the genome in a number of different organisms. These have driven the development of various computational methods for identifying periodical expressed genes. However, the agreement is remarkably poor when different computational methods are applied to the same data. In view of this, we are motivated to propose herein a hybrid computational method targeting the identification of periodically expressed genes, which is based on a hybrid aggregation of estimations, generated by different computational methods. The proposed hybrid method is benchmarked against three other computational methods for the identification of periodically expressed genes: statistical tests for regulation and periodicity and a combined test for regulation and periodicity. The hybrid method is shown, together with the combined test, to statistically significantly outperform the statistical test for periodicity. However, the hybrid method is also demonstrated to be significantly better than the combined test for regulation and periodicity.
Subject: Computer Science\Artificial Intelligence
Medical Sciences
Mathematics\General
Keywords: computational method, cell cycle-regulated genes, P-value for regulation, P-value for periodicity, hybrid aggregation
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