5-y follow-up study of patients with neuroborreliosis

Document type: Journal Articles
Article type: Original article
Peer reviewed: Yes
Author(s): Johan Berglund, Louise Stjernberg, Katharina Ornstein, Katarina Tykesson/Joelsson, Hallstein Walter
Title: 5-y follow-up study of patients with neuroborreliosis
Journal: Scandinavian Journal of Infectious Diseases
Year: 2002
Volume: 34
Issue: 6
Pagination: 421-425
ISSN: 0036-5548
Publisher: Taylor & Francis
URI/DOI: 10.1080/00365540110080421
ISI number: 000177058300005
Organization: Blekinge Institute of Technology
Department: School of Engineering - Dept. Mathematics and Science (Sektionen för teknik – avd. för matematik och naturvetenskap)
School of Engineering S- 371 79 Karlskrona
+46 455 38 50 00
Authors e-mail: louise.stjernberg@bth.se
Language: English
Abstract: The objective of this follow-up study was to determine the long-term outcome of strictly classified cases of neuroborreliosis treated with antibiotics.
A one-year prospective population-based survey of Lyme borreliosis was conducted in southern Sweden, between 1992 and 1993. A total of 349 identified cases with suspected neuroborreliosis were followed up 5 years later. Medical records were reviewed and all participants filled in a questionnaire. Of those classified with definite neuroborreliosis 114/130 completed the follow-up, of whom 111 had completed the initial antibiotic treatment. Of the 114 patients followed up, 86 (75%) had recovered completely and 70 (61%) had recovered within 6 months. Residual neurological symptoms such as facial palsy, concentration disorder, paresthesia and/or neuropathy were reported by 28/114. No significant differences between different antibiotic treatments were observed in terms of occurrence of sequelae.
To conclude, we found that 25% (95% confidence interval 17-33%) of the patients suffered from residual neurological symptoms 5 years post-treatment. However, the clinical outcome of treated neuroborreliosis is favourable as only 14/114 (12%) of the patients had sequelae that influenced their daily activity post-treatment. Early diagnosis and treatment would seem to be of great importance in order to avoid such sequelae.
Subject: Public Health\General
Keywords: neuroborreliosis, ticks follow-up