A tetravalent meningococcal serogroups A, C, W-135, and Y tetanus toxoid conjugate vaccine is immunogenic and well-tolerated when co-administered with Twinrix

Document type: Journal Articles
Article type: Original article
Peer reviewed: Yes
Author(s): Lars Ostergaard, Sven-Arne Silfverdal, Johan Berglund, Carl-Erik Flodmark, Christina West, Veronique Bianco, Yaela Baine, Jacqueline M. Miller
Title: A tetravalent meningococcal serogroups A, C, W-135, and Y tetanus toxoid conjugate vaccine is immunogenic and well-tolerated when co-administered with Twinrix
Journal: Vaccine
Year: 2012
Volume: 30
Issue: 4
Pagination: 774-783
ISSN: 0264-410X
Publisher: Elsevier
ISI number: 000300263700012
Organization: Blekinge Institute of Technology
Department: School of Health Science (Sektionen för hälsa)
School of Health Science S-371 79 Karlskrona
+46 455 38 50 00
http://www.bth.se/hal/
Language: English
Abstract: The co-administration of the tetravalent meningococcal conjugate vaccine, MenACWY-TT, with a licensed hepatitis A and B vaccine, HepA/B (Twinrix (R)), was compared to their separate administration in this open, randomised, controlled study. Healthy subjects 11-17 years of age (n = 611) were randomised (3:1:1) to receive both vaccines, MenACWY-TT alone or HepA/B alone. The co-administration of both vaccines was shown to be non-inferior to their individual administration. At seven months after the first vaccination, 99.4-100% of the subjects who received both vaccines co-administered showed seroprotection against all meningococcal serogroups and at least 99.1% of them were seropositive for hepatitis A and seroprotected against hepatitis B. This study suggests that MenACWY-TT vaccine could be co-administered with HepA/B without adversely impacting the immunogenicity, safety and reactogenicity of either of the vaccines.
Subject: Medical Sciences
Keywords: Co-administration, Tetravalent meningococcal vaccine, Conjugate vaccine, Twinrix (R), Adolescent
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