A tetravalent meningococcal serogroups A, C, W-135, and Y tetanus toxoid conjugate vaccine is immunogenic and well-tolerated when co-administered with Twinrix
| Document type: | Journal Articles |
|---|---|
| Article type: | Original article |
| Peer reviewed: | Yes |
| Author(s): | Lars Ostergaard, Sven-Arne Silfverdal, Johan Berglund, Carl-Erik Flodmark, Christina West, Veronique Bianco, Yaela Baine, Jacqueline M. Miller |
| Title: | A tetravalent meningococcal serogroups A, C, W-135, and Y tetanus toxoid conjugate vaccine is immunogenic and well-tolerated when co-administered with Twinrix |
| Journal: | Vaccine |
| Year: | 2012 |
| Volume: | 30 |
| Issue: | 4 |
| Pagination: | 774-783 |
| ISSN: | 0264-410X |
| Publisher: | Elsevier |
| ISI number: | 000300263700012 |
| Organization: | Blekinge Institute of Technology |
| Department: | School of Health Science (Sektionen för hälsa) School of Health Science S-371 79 Karlskrona +46 455 38 50 00 http://www.bth.se/hal/ |
| Language: | English |
| Abstract: | The co-administration of the tetravalent meningococcal conjugate vaccine, MenACWY-TT, with a licensed hepatitis A and B vaccine, HepA/B (Twinrix (R)), was compared to their separate administration in this open, randomised, controlled study. Healthy subjects 11-17 years of age (n = 611) were randomised (3:1:1) to receive both vaccines, MenACWY-TT alone or HepA/B alone. The co-administration of both vaccines was shown to be non-inferior to their individual administration. At seven months after the first vaccination, 99.4-100% of the subjects who received both vaccines co-administered showed seroprotection against all meningococcal serogroups and at least 99.1% of them were seropositive for hepatitis A and seroprotected against hepatitis B. This study suggests that MenACWY-TT vaccine could be co-administered with HepA/B without adversely impacting the immunogenicity, safety and reactogenicity of either of the vaccines. |
| Subject: | Medical Sciences |
| Keywords: | Co-administration, Tetravalent meningococcal vaccine, Conjugate vaccine, Twinrix (R), Adolescent |
