Systemic antibiotics and debridement of peri-implant mucositis. A randomized clinical trial

Document type: Journal Articles
Article type: Original article
Peer reviewed: Yes
Author(s): Hadar Hallström, Rutger Persson, Susann Lindgren, Maria Olofsson, Stefan Renvert
Title: Systemic antibiotics and debridement of peri-implant mucositis. A randomized clinical trial
Journal: Journal of Clinical Periodontology
Year: 2012
Volume: 39
Issue: 6
Pagination: 574-581
ISSN: 0303-6979
Publisher: Wiley Blackwell
URI/DOI: 10.1111/j.1600-051X.2012.01884.x
ISI number: 000303855200009
Organization: Blekinge Institute of Technology
Department: School of Health Science (Sektionen för hälsa)
School of Health Science S-371 79 Karlskrona
+46 455 38 50 00
Language: English
Abstract: Background This RCT compared non-surgical treatment of peri-implant mucositis with or without systemic antibiotics. Materials and Methods Forty-eight subjects received non-surgical debridement with or without systemic Azithromax (R) (4 similar to days), and were followed during 6 similar to months. The checkerboard DNA-DNA hybridization method was used to analyse the microbiological material. Results Five subjects were excluded due to antibiotic medication during follow-up. At baseline,1 and 3 similar to months no group differences were found. Statistical analysis failed to demonstrate differences in probing pocket depths (PPD) values at 6 similar to months (Mean diff PPD: 0.5 similar to mm, SE: +/- 0.4 similar to mm, 95% CI: -0.2, 1.3, p similar to 0.16). Mean% implant bleeding decreased between baseline and month 6 from 82.6% to 27.3% in the test, and from 80.0% to 47.5% in the control group (p similar to 0.02). Throughout the study, no study group differences in bacterial counts were found. Conclusion No short-term differences were found between study groups. The clinical improvements observed at 6 similar to months may be attributed to improvements in oral hygiene. The present study does not provide evidence for the use of systemic antibiotics in treatment of peri-implant mucositis.
Subject: Medical Sciences
Keywords: antibiotics, microbiology, peri-implant disease, peri-implant mucositis, therapy